.disease-overview-panel.disease-overview-enhanced {
  padding: 0;
  overflow: hidden;
  border-top: 4px solid #245f8f;
}

.disease-overview-enhanced .disease-overview-header {
  padding: 17px 20px 14px;
}

.disease-overview-enhanced > .analysis-cohort-summary {
  display: grid;
  grid-template-columns: 1fr;
  gap: 13px;
  padding: 16px 20px;
}

.disease-overview-enhanced .analysis-metric-grid {
  grid-area: auto;
  order: 0;
  width: 100%;
  padding: 0;
}

.disease-overview-enhanced .analysis-cohort-breakdown {
  order: 1;
}

.disease-transcriptome-overview {
  display: grid;
  gap: 14px;
  padding: 0 20px 20px;
  background: #fff;
}

.disease-overview-toolbar {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 14px;
  padding-top: 15px;
  border-top: 1px solid #dce3eb;
}

.disease-overview-toolbar label {
  display: flex;
  align-items: center;
  gap: 9px;
  color: #24384f;
  font-size: 0.82rem;
  font-weight: 700;
}

.disease-overview-toolbar select {
  min-width: 310px;
  min-height: 36px;
  padding: 5px 30px 5px 9px;
  border: 1px solid #bdcad8;
  background: #fff;
  color: #24384f;
}

.disease-overview-toolbar > span {
  color: #617087;
  font-size: 0.8rem;
  text-transform: none;
}

.disease-overview-primary-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 16px;
  align-items: stretch;
}

.disease-overview-umap-panel,
.disease-overview-composition-panel {
  min-width: 0;
  border: 1px solid #d5e0ea;
  border-radius: 6px;
  overflow: hidden;
  background: #fff;
}

.disease-study-umap-canvas {
  display: block;
  width: 100% !important;
  max-width: 100%;
  height: auto;
  background: #fff;
}

.disease-overview-umap-panel .study-umap-legend {
  padding: 10px 12px;
  border-top: 1px solid #e2e8f0;
}

.disease-overview-composition-panel {
  display: flex;
  flex-direction: column;
  max-height: 620px;
}

.disease-overview-panel-heading {
  padding: 13px 14px 9px;
  border-bottom: 1px solid #e2e8f0;
  background: #f8fafc;
}

.disease-overview-panel-heading h4,
.disease-overview-panel-heading p {
  margin: 0;
}

.disease-overview-panel-heading h4 {
  color: #1f2d40;
  font-size: 1rem;
  line-height: 1.25;
}

.disease-overview-panel-heading p {
  margin-top: 4px;
  color: #64748b;
  font-size: 0.76rem;
  line-height: 1.35;
}

.disease-overview-composition-legend {
  display: flex;
  flex-wrap: wrap;
  gap: 6px 10px;
  padding: 9px 12px;
  border-bottom: 1px solid #e2e8f0;
  color: #526173;
  font-size: 0.68rem;
  line-height: 1.25;
}

.disease-overview-composition-legend span,
.disease-overview-umap-panel .study-umap-legend span {
  display: inline-flex;
  align-items: center;
  gap: 4px;
}

.disease-overview-composition-legend i {
  display: inline-block;
  width: 8px;
  height: 8px;
  flex: 0 0 8px;
  border-radius: 2px;
}

.disease-overview-composition-rows {
  overflow: auto;
  padding: 5px 10px 9px;
}

.disease-overview-composition-row {
  display: grid;
  grid-template-columns: minmax(92px, 1fr) minmax(130px, 2.2fr) 54px;
  gap: 7px;
  align-items: center;
  min-height: 31px;
  border-bottom: 1px solid #edf2f6;
  color: #526173;
  font-size: 0.71rem;
}

.disease-overview-composition-row strong {
  overflow: hidden;
  color: #2b3c50;
  text-overflow: ellipsis;
  white-space: nowrap;
}

.disease-overview-composition-row > span {
  text-align: right;
  font-variant-numeric: tabular-nums;
}

.disease-overview-composition-track {
  display: flex;
  height: 17px;
  overflow: hidden;
  border: 1px solid #d5dfe8;
  border-radius: 3px;
  background: #eef2f6;
}

.disease-overview-segment {
  display: flex;
  align-items: center;
  justify-content: center;
  height: 100%;
  min-width: 0;
  overflow: hidden;
  color: #fff;
  font-size: 9px;
  font-weight: 800;
  line-height: 1;
  text-shadow: 0 1px 2px rgba(15, 23, 42, 0.65);
}

.disease-overview-loading {
  padding: 28px 18px;
  color: #64748b;
  text-align: center;
}

@media (max-width: 1180px) {
  .disease-overview-primary-grid {
    grid-template-columns: 1fr;
  }

  .disease-overview-composition-panel {
    max-height: 520px;
  }
}

@media (max-width: 760px) {
  .disease-overview-enhanced .analysis-metric-grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .disease-overview-toolbar {
    align-items: stretch;
    flex-direction: column;
  }

  .disease-overview-toolbar label {
    align-items: stretch;
    flex-direction: column;
  }

  .disease-overview-toolbar select {
    width: 100%;
    min-width: 0;
  }
}