.analysis-cohort-summary {
  display: grid;
  gap: 14px;
  width: 100%;
}

.analysis-cohort-breakdown {
  display: grid;
  gap: 10px;
  padding: 14px 16px;
  border: 1px solid #d7e0ea;
  border-radius: 6px;
  background: #fff;
}

.analysis-cohort-breakdown > div {
  display: grid;
  grid-template-columns: 112px minmax(0, 1fr);
  gap: 14px;
  align-items: start;
}

.analysis-cohort-breakdown strong {
  color: #1f3f63;
  font-size: 0.86rem;
}

.analysis-cohort-breakdown p {
  min-width: 0;
  margin: 0;
  color: #3f4f63;
  font-size: 0.86rem;
  line-height: 1.6;
  overflow-wrap: anywhere;
  text-transform: none;
}

@media (max-width: 720px) {
  .analysis-cohort-breakdown > div {
    grid-template-columns: 1fr;
    gap: 3px;
  }
}

.analysis-receptor-feature-grid {
  display: grid;
  grid-template-columns: minmax(0, 1.1fr) minmax(0, 0.9fr);
  gap: 16px;
  padding: 16px;
  background: #fff;
}

.analysis-receptor-panel {
  min-width: 0;
  border: 1px solid #d7e0ea;
  border-radius: 6px;
  overflow: hidden;
  background: #fff;
}

.analysis-receptor-panel > h4,
.analysis-receptor-panel > p {
  margin-right: 16px;
  margin-left: 16px;
}

.analysis-receptor-panel > h4 {
  margin-top: 14px;
  margin-bottom: 3px;
  color: #1f3f63;
  font-size: 1rem;
}

.analysis-receptor-panel > p {
  margin-top: 0;
  margin-bottom: 12px;
  color: #607086;
  font-size: 0.8rem;
  line-height: 1.45;
  text-transform: none;
}

.analysis-receptor-panel .table-wrap {
  max-height: 560px;
  border-top: 1px solid #e2e8f0;
  overflow: auto;
}

.analysis-receptor-table {
  width: 100%;
  min-width: 680px;
  border-collapse: collapse;
  table-layout: auto;
}

.analysis-receptor-table th,
.analysis-receptor-table td {
  padding: 8px 10px;
  border-bottom: 1px solid #e8edf3;
  font-size: 0.76rem;
  line-height: 1.35;
  text-align: left;
  white-space: nowrap;
}

.analysis-receptor-table th {
  position: sticky;
  top: 0;
  z-index: 1;
  background: #f4f7fa;
  color: #334155;
}

.analysis-receptor-table td:nth-child(n + 3),
.analysis-receptor-table th:nth-child(n + 3) {
  text-align: right;
}

@media (max-width: 1100px) {
  .analysis-receptor-feature-grid {
    grid-template-columns: 1fr;
  }
}

.analysis-workflow-tabs {
  position: sticky;
  top: 0;
  z-index: 8;
  display: flex;
  gap: 4px;
  padding: 6px;
  border: 1px solid #d4dde8;
  background: #fff;
}

.analysis-workflow-tabs a {
  padding: 8px 13px;
  color: #294968;
  font-size: 0.82rem;
  font-weight: 700;
  text-decoration: none;
  white-space: nowrap;
}

.analysis-workflow-tabs button,
.analysis-clonal-tabs button,
.disease-receptor-tabs button {
  border: 0;
  background: transparent;
  color: #294968;
  cursor: pointer;
  font: inherit;
  font-weight: 700;
}

.analysis-workflow-tabs button {
  padding: 8px 13px;
  white-space: nowrap;
}

.analysis-workflow-tabs button.active,
.analysis-clonal-tabs button.active,
.disease-receptor-tabs button.active {
  background: #e7f1f9;
  color: #123f6d;
}

.analysis-workflow-tabs a:hover,
.analysis-workflow-tabs a:focus-visible {
  background: #eef5fb;
  color: #123f6d;
}

.analysis-scope-note {
  padding: 12px 15px;
  border-left: 3px solid #2b6f9f;
  background: #f3f8fc;
  color: #3d5268;
  font-size: 0.84rem;
  text-transform: none;
}

.disease-overview-panel {
  padding: 16px;
}

.analysis-clonal-tabs,
.disease-receptor-tabs {
  display: flex;
  flex-wrap: wrap;
  gap: 5px;
  padding: 6px;
  border: 1px solid #d5dee8;
  background: #fff;
}

.analysis-clonal-tabs button,
.disease-receptor-tabs button {
  padding: 8px 12px;
}

.disease-analysis-scope.disease-tab-overview .analysis-section-card,
.disease-analysis-scope.disease-tab-receptor .analysis-section-card:not(.analysis-receptor-features-card),
.disease-analysis-scope.disease-tab-clonal .analysis-receptor-features-card {
  display: none;
}

.disease-analysis-scope.disease-tab-receptor .analysis-scope-note,
.disease-analysis-scope.disease-tab-clonal .analysis-scope-note {
  display: none;
}

.disease-analysis-scope.disease-tab-clonal.clonal-group-maturation .analysis-clonal-prioritization,
.disease-analysis-scope.disease-tab-clonal.clonal-group-maturation .analysis-clonal-convergence,
.disease-analysis-scope.disease-tab-clonal.clonal-group-prioritization .analysis-clonal-maturation,
.disease-analysis-scope.disease-tab-clonal.clonal-group-prioritization .analysis-clonal-convergence,
.disease-analysis-scope.disease-tab-clonal.clonal-group-convergence .analysis-clonal-maturation,
.disease-analysis-scope.disease-tab-clonal.clonal-group-convergence .analysis-clonal-prioritization {
  display: none;
}

.disease-receptor-landscape {
  display: grid;
  gap: 14px;
  padding: 16px;
  background: #fff;
}

.disease-receptor-toolbar {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 14px;
}

.disease-receptor-toolbar label {
  display: flex;
  align-items: center;
  gap: 8px;
  color: #334155;
  font-size: 0.8rem;
  font-weight: 700;
}

.disease-receptor-toolbar select {
  min-height: 36px;
  padding: 5px 30px 5px 9px;
  border: 1px solid #bdcad8;
  background: #fff;
}

.disease-receptor-toolbar > span,
.disease-pairing-note {
  color: #65758a;
  font-size: 0.8rem;
  text-transform: none;
}

.receptor-horizontal-bars {
  display: grid;
  gap: 7px;
}

.receptor-bar-row {
  display: grid;
  grid-template-columns: minmax(150px, 1.2fr) minmax(180px, 3fr) 90px minmax(170px, 1.2fr);
  gap: 10px;
  align-items: center;
  min-width: 0;
}

.receptor-bar-row > span {
  overflow: hidden;
  color: #314155;
  font-size: 0.78rem;
  text-overflow: ellipsis;
  white-space: nowrap;
}

.receptor-bar-row > div {
  height: 14px;
  background: #edf2f6;
}

.receptor-bar-row i {
  display: block;
  height: 100%;
  background: #2f78a8;
}

.receptor-bar-row strong,
.receptor-bar-row small {
  font-size: 0.76rem;
  text-align: right;
}

.receptor-bar-row small {
  color: #65758a;
}

.vhvl-heatmap-wrap {
  display: grid;
  grid-template-columns: minmax(105px, auto) repeat(12, minmax(42px, 1fr));
  gap: 3px;
  min-width: 860px;
  overflow-x: auto;
}

.vhvl-corner,
.vhvl-col-label,
.vhvl-row-label {
  display: flex;
  align-items: center;
  min-height: 42px;
  color: #475569;
  font-size: 0.68rem;
  font-weight: 700;
}

.vhvl-col-label {
  justify-content: center;
  writing-mode: vertical-rl;
  transform: rotate(180deg);
}

.vhvl-cell {
  min-height: 38px;
  border: 0;
  cursor: pointer;
  font-size: 0.68rem;
}

.vhvl-selected {
  display: flex;
  flex-wrap: wrap;
  gap: 8px 18px;
  padding: 11px 13px;
  border-left: 3px solid #2f78a8;
  background: #f2f7fb;
  color: #405167;
  font-size: 0.8rem;
}

@media (max-width: 760px) {
  .disease-receptor-toolbar,
  .receptor-bar-row {
    align-items: stretch;
    grid-template-columns: 1fr;
  }

  .disease-receptor-toolbar {
    flex-direction: column;
  }

  .receptor-bar-row strong,
  .receptor-bar-row small {
    text-align: left;
  }
}

.study-transcriptome-overview {
  display: grid;
  gap: 14px;
  padding: 16px;
  background: #fff;
}

.study-umap-toolbar,
.study-tissue-compare-header,
.study-tissue-compare-header > div:last-child {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 12px;
}

.study-umap-toolbar label {
  display: flex;
  align-items: center;
  gap: 8px;
  font-size: 0.82rem;
  font-weight: 700;
}

.study-umap-toolbar select,
.study-tissue-compare select {
  min-height: 36px;
  padding: 5px 30px 5px 9px;
  border: 1px solid #bdcad8;
  background: #fff;
  color: #24384f;
}

.study-umap-toolbar > span {
  color: #617087;
  font-size: 0.8rem;
  text-transform: none;
}

.study-umap-canvas {
  display: block;
  width: 100%;
  height: auto;
  border: 1px solid #d7e0e9;
  background: #fff;
}

.study-umap-legend {
  display: flex;
  flex-wrap: wrap;
  gap: 6px 12px;
}

.study-umap-legend > span {
  display: inline-flex;
  align-items: center;
  gap: 5px;
  color: #46566a;
  font-size: 0.75rem;
  text-transform: none;
}

.study-umap-legend i {
  width: 9px;
  height: 9px;
  border-radius: 50%;
}

.study-tissue-compare {
  display: grid;
  gap: 12px;
  margin-top: 6px;
  padding-top: 16px;
  border-top: 1px solid #dce3eb;
}

.study-tissue-compare h4,
.study-tissue-compare h5,
.study-tissue-compare p {
  margin: 0;
}

.study-tissue-compare h4 {
  color: #1f3f63;
  font-size: 1rem;
}

.study-tissue-compare p {
  color: #637287;
  font-size: 0.8rem;
  text-transform: none;
}

.study-tissue-compare-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 14px;
}

.study-tissue-compare-grid > section {
  min-width: 0;
  padding: 12px;
  border: 1px solid #d7e0e9;
  background: #fff;
}

.study-tissue-compare-grid h5 {
  margin-bottom: 9px;
  color: #283f58;
  font-size: 0.9rem;
}

.study-tissue-composition {
  display: grid;
  gap: 4px;
  margin-top: 10px;
}

.study-tissue-composition > div {
  display: grid;
  grid-template-columns: minmax(0, 1fr) auto 52px;
  gap: 8px;
  padding: 4px 0;
  border-bottom: 1px solid #edf1f5;
  color: #4a596c;
  font-size: 0.75rem;
}

.study-tissue-composition em {
  color: #64748b;
  font-style: normal;
  text-align: right;
}

.repertoire-pair-browser {
  margin-top: 18px;
  border-top: 1px solid #dce5ef;
  padding-top: 18px;
}

.repertoire-pair-toolbar {
  display: flex;
  align-items: flex-end;
  justify-content: space-between;
  gap: 18px;
  margin-bottom: 12px;
}

.repertoire-pair-toolbar h4 {
  margin: 0 0 4px;
  color: #172033;
  font-size: 1.05rem;
}

.repertoire-pair-toolbar p,
.repertoire-comparison-caveat {
  margin: 0;
  color: #64748b;
  font-size: 0.82rem;
  line-height: 1.5;
}

.repertoire-pair-filters {
  display: flex;
  gap: 10px;
}

.repertoire-pair-filters label {
  display: grid;
  gap: 4px;
  color: #526174;
  font-size: 0.72rem;
  font-weight: 700;
}

.repertoire-pair-filters select {
  min-width: 150px;
  padding: 7px 30px 7px 9px;
  border: 1px solid #cbd7e5;
  background: #fff;
  color: #263449;
}

.repertoire-pair-table-wrap {
  max-height: 520px;
  overflow: auto;
}

.repertoire-pair-table {
  min-width: 1180px;
  width: 100%;
}

.repertoire-pair-table th,
.repertoire-pair-table td {
  padding: 8px 10px;
  vertical-align: top;
  font-size: 0.76rem;
  line-height: 1.35;
}

.repertoire-pair-badges {
  display: flex;
  flex-wrap: wrap;
  gap: 4px;
}

.repertoire-pair-badges span {
  display: inline-block;
  padding: 2px 6px;
  border: 1px solid #bfd5e8;
  background: #eef6fc;
  color: #285d85;
  font-size: 0.68rem;
  font-weight: 700;
  white-space: nowrap;
}

.repertoire-pair-badges span.cross {
  border-color: #e6c8a4;
  background: #fff7ed;
  color: #9a5a16;
}

.repertoire-comparison-caveat {
  margin-top: 10px;
  padding: 9px 11px;
  border-left: 3px solid #7299bb;
  background: #f6f9fc;
}

@media (max-width: 820px) {
  .analysis-workflow-tabs {
    overflow-x: auto;
  }

  .study-umap-toolbar,
  .study-tissue-compare-header {
    align-items: flex-start;
    flex-direction: column;
  }

  .study-tissue-compare-grid {
    grid-template-columns: 1fr;
  }

  .repertoire-pair-toolbar,
  .repertoire-pair-filters {
    align-items: stretch;
    flex-direction: column;
  }
}